San Lorenzo defeated Independiente Medellín (DIM) just like in the first leg, but this time at home and with a 2-0 score, to secure their spot in the Copa Sudamericana round of 16, where they will face Sao Paulo.

A brace from Paraguayan Adam Bareiro, with two penalty goals (25' and 80'), allowed 'Ciclón' to complete a resounding 3-0 aggregate victory."