Lloris made clear earlier this summer his desire for a new challenge after 11 years at Spurs and was not involved in the 2-2 draw at Brentford.

The World Cup winner is now closing in on a switch to Lazio after talks between the clubs started, but a final agreement on a fee is still to be reached, the PA news agency understands.

If Lloris does leave, as has always been expected in this transfer window, his final appearance for Tottenham would be the thumping 6-1 loss at Newcastle in April.

A thigh injury ruled Lloris out of the final weeks of the campaign and the French keeper revealed in June his desire “to do other things” in the future.

While no move was forthcoming during the early part of the transfer window, Spurs’ focus was on Bayern Munich’s public pursuit of Harry Kane and incomings with James Maddison able to sign.

Lloris was left out of the club’s pre-season tour of Perth, Bangkok and Singapore in July to explore transfer opportunities, but Kane moved on before the Frenchman with his switch to Bayern finalised on Saturday.

Spurs announced their new captain on the same day with Son Heung-min named as Lloris’ successor, while Cristian Romeo and Maddison were listed as vice-captains.

Lloris retained his number one shirt when Tottenham unveiled their squad numbers on Sunday, but he was left out of the squad at Brentford despite back-up goalkeeper Fraser Forster injured with a back problem.

It meant academy graduate Brandon Austin was named on the bench as deputy to new number one Guglielmo Vicario, who endured some nervy moments on his Premier League debut.

Vicario will be able to move forward at Tottenham without the shadow of Lloris after talks between Lazio and the club stepped up this week.

With Lloris still having a year left on his contract, Spurs hope to get a fee for their former captain but it is now expected the 36-year-old will begin the next chapter of his career in Italy.

Lloris will leave Tottenham after 447 appearances and 151 clean sheets, having helped the club reach three finals during his 11 years, including the 2019 Champions League Final.