The 34-year-old defender took his tally to triple figures with a towering header against the Italians, in his 659th appearance for the club.
Captain Fantastic!— Champions League on CBS Sports (@UCLonCBSSports) November 3, 2020
Sergio Ramos gets the second goal of the day and his 100th goal for Real Madrid. pic.twitter.com/P4wiyIiLER
It was the centre-back's 13th goal in the Champions League and put Madrid 2-0 up after Karim Benzema's opener, though Lautaro Martinez reduced the arrears before half-time.
Ramos became the highest-scoring defender in LaLiga history last July and made his 500th appearance in the competition at the weekend.