The Brazil star had been out of action for a month due to injury but was fit enough to start at Parc des Princes on Friday, though fellow forward Kylian Mbappe, who has been ill, was only deemed ready for the bench.
Mbappe's initial absence did not hurt PSG as on-loan striker Mauro Icardi hit his ninth goal in his past eight appearances to put his side in front.
1/17 - Mauro Icardi scored on his third touch of the game tonight. He scores a goal every 17 touches in Ligue 1 this season, best rate among the Top 5 European Leagues. Fox. pic.twitter.com/zBm4COZomR— OptaJean (@OptaJean) November 22, 2019
Angel Di Maria struck the second before half-time and Mbappe came off the bench to make it a good day for coach Thomas Tuchel ahead of Tuesday's Champions League trip to Real Madrid.
Icardi continued his hot streak with the opening goal for PSG in the 17th minute, the Argentina attacker arriving at the back post to convert Idrissa Gueye's left-wing cross.
PSG had not hit top gear but doubled their advantage before the half-time break.
11 - There are 11 points between the first and the second of Ligue 1 2019/20, as many as between the second and the last of the league. Solo. pic.twitter.com/Qpiv5S8vxd— OptaJean (@OptaJean) November 22, 2019
When Neymar was tackled the ball ran loose for Julian Draxler to trick his way into space and free Di Maria in the left channel to beat Mike Maignan with a trademark left-foot curler.
Though Keylor Navas had to save well from Luiz Araujo, such was PSG's comfort that Neymar was able to make way for Mbappe's return midway through the second half.
Lille substitute Loic Remy had a chance to set up a grandstand finish but scuffed a tame finish at Navas, while Yusuf Yazici curled wide from a promising position in the closing stages.
What does it mean? Another title looks certain for PSG
Despite already having lost three times in the league this season, PSG are 11 points clear and seemingly cruising to another Ligue 1 crown. The challenge for Tuchel will be maintaining momentum and intensity for key Champions League clashes still to come.
Lille lost vital members of their coaching staff to Tottenham after Jose Mourinho's appointment this week and Christophe Galtier's side, who have only won once in the league since September, face a battle to secure Champions League football.
Gueye adds to clean sheet collection
PSG's array of attacking talent is the envy of clubs from all over the world but Gueye, who joined from Everton ahead of the 2018-19 season, may prove their most important signing in some time.
The Senegal midfielder has now played nine Ligue 1 matches for his new club and they have won eight of them, conceding just three times. As well as providing protection for PSG's defence, he created the opening goal for Icardi with a fine low cross.
Draxler miss not punished by Lille
PSG should have won by a greater margin but Draxler, who had otherwise been impressive, wasted a superb chance to add to their lead early in the second half after being set up by Icardi.
Substitute Edinson Cavani, who replaced Icardi, was also profligate in the last minute.
PSG are already through to the next round of the Champions League but can secure top spot by avoiding defeat away to Real Madrid on Tuesday, with Tuchel's side back in domestic action next Sunday when they go to Monaco.
Lille are at home to Ajax on Wednesday then host Dijon in the league three days later.