Neymar suffered a rib injury during a 5-0 thrashing of Montpellier last weekend and sat out the 2-1 victory at Nantes on Tuesday, having thrown a lavish party 48 hours earlier to celebrate his 28th birthday.
He trained on Friday, but PSG boss Thomas Tuchel revealed the former Barcelona man will not feature in the Ligue 1 clash with Rudi Garcia's side at the Parc des Princes.
🎙 Coach Tuchel: “Dagba, Bernat, Diallo will be absent against Lyon. @marquinhos_m5, @neymarjr and @tsilva3— Paris Saint-Germain (@PSG_English) February 8, 2020
trained with us this morning but tomorrow’s game is too early." #PSGlive pic.twitter.com/B3SSzf3ezO
Bernat has recovered from a calf injury, but the full-back misses out after falling ill.
Thiago Silva is not ready to return from a hip problem, although the centre-back has also been able to resume training this week and the same goes for fellow defenders Marquinhos (calf) and Abdou Diallo (thigh).
Colin Dagba is another player unavailable to Tuchel due to a knee injury as PSG look to extend their unbeaten run to 21 matches in all competitions.
The champions are 12 points clear of Marseille at the top of the table.