While Uruguay have labored to find their form in the tournament, Paraguay have taken six points from the first three Group A matches.
They defeated Chile 2-0 on Thursday to confirm their place in the quarter-finals, three days after Uruguay needed an own goal by Arturo Vidal to salvage a 1-1 draw with La Roja.
Coupled with a tournament-opening defeat of Bolivia, Paraguay will be feeling confident about their chances to earn a long-awaited victory.
Head coach Eduardo Berizzo said he expects the game to unfold along similar lines as the sides' scoreless draw in World Cup qualifying in Montevideo earlier this month.
"Uruguay is tough, difficult, we faced each other recently in the qualifying rounds, it was very physical and tactical and surely the same awaits us," he said. "We will go out to win as we always do."
La Celeste broke a five-game winless streak with a 2-0 defeat of Bolivia in their previous match, with Edinson Cavani breaking through for his first international goal since Uruguay's most recent victory against Colombia in November.
With qualification for the knockout phase ensured, Uruguay will hope to gain their footing against a side they have dominated for decades.
Uruguay are unbeaten in 15 Copa America games (W9 D6) against Paraguay dating to that long-forgotten La Albirroja triumph 74 years ago.
PLAYERS TO WATCH
Uruguay – Luis Suarez
Suarez is responsible for five of Uruguay's 12 shots on target in the tournament, a sign that he may be close to breaking his five-game international scoring drought.
Beyond that stretch, the Atletico striker has not scored in the run of play for his country since a November 2019 friendly draw with Argentina. His four goals in World Cup qualifying last fall each came from the spot.
Paraguay – Miguel Almiron
The Newcastle man had a hand in both goals against Chile, assisting on Braian Samudio's 33rd-minute opener and scoring from the spot in the second half.
KEY OPTA FACTS
- After their last win against Bolivia, Uruguay broke a run of three winless games in Copa America (D2 L1). They also scored two goals after scoring just once in each of the previous four (W1 D2 L1).
- After 11 winless games in Copa America (D6 L5), Paraguay won two of their last three games losing just against Argentina (1-0).
- Paraguay are the team with the higher shooting average in the current Copa America (17). The Albirroja also have the highest tally in a single game in the competition: 34 shots against Bolivia.