The format of the 2021 tournament means just one team from each section misses out on the last eight, though the final matches are still pivotal as nations jostle for positions in the final standings.
Bolivia's exit was confirmed with a 2-0 reverse against Uruguay last time out, another blank in front of goal meaning Cesar Farias' side have managed to score just once in three outings so far.
Argentina have also found it tough going in attack, despite the presence of the talismanic Lionel Messi. Following a 1-1 draw with Chile in their opener, they have recorded back-to-back 1-0 triumphs over Uruguay and Paraguay.
Those results mean head coach Scaloni has not seen his team lose in his previous 16 games. His last defeat in the job came in the previous edition of the Copa America, as they were knocked out by rivals Brazil in the 2019 semi-finals.
A potential rematch appears unlikely until the final this time around, with Brazil winning Group B. Argentina know a victory in Cuiaba will be enough for them to do the same ahead of the quarter-finals.
Scaloni has a decision to make over whether to rest Messi, who has played every minute in the competition so far.
While the Barcelona superstar just recently turned 34, he may want to be involved from the start as he looks to win his 148th international cap, which would move him out of a tie with Javier Mascherano to sit alone at the top of the list for Argentina appearances.
Those in danger of receiving a suspension with another yellow card on Monday are likely to be left out, among them Lautaro Martinez, Leandro Paredes and Giovanni Lo Celso.
PLAYERS TO WATCH
Argentina - Alejandro Gomez
'Papu' Gomez arrived late to international football but helped make up for lost time in his previous outing with his first goal in a competitive fixture for Argentina. He struck in the 10th minute against Paraguay, while he also completed 88.2 per cent of his attempted passes in the opposition half before being substituted. Did he do enough to keep his place, though?
Bolivia - Carlos Lampe
Goalkeeper Lampe has been a rare positive for his team at the Copa America, making the most saves per game (eight) among those to have played in two or more fixtures. Even with Argentina potentially resting players, Bolivia's last line of defence may well be busy again as they prepare to say farewell to this year's Copa.
KEY OPTA FACTS
- This will be the 10th meeting in the Copa America at a neutral venue, with Argentina never previously losing in such contests (W9 D1). However, Bolivia have won twice when serving as competition hosts, in 1963 and 1979.
- Scaloni is unbeaten in his last 16 managerial games in all competitions, his best run since taking charge of Argentina (W9 D7).
- After five unbeaten games in the Copa America with Venezuela, Cesar Farias has lost the last four; one for Venezuela (semi-final in 2011) and three for Bolivia (all this year).
- Argentina are the team with the most goals scored in the first 15 minutes of their games (two), with all of their goals scored in the first half of games (three, same as Ecuador).