Nacional de Uruguay faced Libertad from Paraguay in Matchday 1 of the 2024 Copa Libertadores. In this Group Stage encounter, the Uruguayans secured a 2-0 victory.

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The goalscorers for the home team were Leandro Lozano with a goal in the 32nd minute and Rúben Betancourt in the 62nd minute, giving Nacional their first three points in Group H.