Manchester United must overcome Europa League specialists Sevilla in order to reach a semifinal against either Juventus or Sporting CP.

United defeated Real Betis in the last 16 and will now face their city rivals Sevilla, six-time winners of the UEFA Cup and Europa League.

The sides have met three times previously, with Sevilla knocking United out of the 2017-18 Champions League over a two-legged tie before beating the Red Devils again in a one-off 2019-20 Europa League semi-final.

It is a daunting draw for United, who could then have to play Juventus in the last four.

The semi-final draw, which was also conducted on Friday, paired the winners of United's tie with Juventus or Sporting, who eliminated Arsenal on Thursday.

Even in the final, should Erik ten Hag's men make it that far, United could be set for a reunion with former manager Jose Mourinho.

Mourinho's Roma were drawn against Feyenoord in the quarterfinals in a repeat of last season's Europa Conference League final, which the Giallorossi won.

Bayer Leverkusen meet Union Saint-Gilloise in the final last-eight tie, playing for the right to face Roma or Feyenoord.

Europa League quarterfinal draw in full:

Manchester United v Sevilla
Juventus v Sporting CP
Bayer Leverkusen v Union Saint-Gilloise
Feyenoord v Roma