Hirving Lozano will miss the last two games of PSV's Eredivisie title tussle with Ajax and is in a race to fitness for this summer's CONCACAF Gold Cup.
Mexico forward Lozano has enjoyed another stellar campaign in the Netherlands, scoring 17 top-flight goals and four in the Champions League.
PSV sit second in the table, level on points with rivals Ajax, as Mark van Bommel seeks to retain the crown won under Phillip Cocu's charge last season.
However, Lozano's season has been cut short due to a knee injury sustained in Thursday's victory over Willem II.
Season with @psv over for Hirving Lozano. Sad way to end it and possibly his career in the Netherlands. No news on whether the injury will keep him out of the Gold Cup. He’s already started his recovery work. #eltrieng https://t.co/fJke1eYAg3— Tom Marshall (@mexicoworldcup) April 29, 2019
Lozano had to be taken off on a stretcher, with PSV fearing ligament damage, and though the club have now confirmed that is not the case, the former Pachuca player will miss the remaining two league fixtures.
"I am relieved that there is no damage to my cruciate ligament, but it is of course very disappointing that I will no longer be on the pitch in the decisive phase of the competition," Lozano told PSV's official website.
"My rehabilitation has started. I am going to do everything to be in top condition as soon as possible."