Maurizio Sarri finally fielded Ronaldo, Paulo Dybala and Gonzalo Higuain together from the start – and the trio were influential in helping the reigning champions record a first victory in three league outings.
The result was a formality by half-time at Allianz Stadium, Ronaldo getting a brace as Udinese struggled to cope with a pumped-up home team eager to bounce back from a 3-1 loss away to Lazio the previous weekend.
The Portugal international opened the scoring in the ninth minute, firing home a loose ball with an instinctive first-time effort, while it was Higuain's well-weighted through ball that set up for a second, finished with his left foot.
Leonardo Bonucci added a third before the interval, flicking in a header at a corner from centre-back partner Merih Demiral via a deflection off the underside of the crossbar, allowing Juve to ease up in the second half.
As the tempo dropped, the hosts relied on the evergreen Gianluigi Buffon - making his 478th Serie A appearance in place of the injured Wojciech Szczesny, drawing him level with Alessandro Del Piero's club record in the competition – to keep Udinese at bay.
The veteran goalkeeper - guilty of a costly error in the 2-2 draw against Sassuolo earlier in December - twice denied the lively Kevin Lasagna, while he also turned away a fierce drive from Seko Fofana.
However, there was little Buffon could do to stop Ignacio Pussetto getting a consolation goal in stoppage time, preventing the former Italy international recording a clean sheet.
Ronaldo had been denied a hat-trick by the post in the closing minutes but Juve coasted to a result that sends them above Inter, although the Nerazzurri can reclaim top spot when they travel to Fiorentina in Sunday's late kick-off.
What does it mean? Sarri sees forwards combine
Having worked so well in the second half of the 2-0 Champions League victory over Bayer Leverkusen in midweek, Dybala, Higuain and Ronaldo had the chance to show they can function from the outset. They did just that, combining impressively on a number of occasions.
So, was Sarri's starting XI a one-off, or a sign of things to come? This was, admittedly, the ideal game to experiment in; Juventus have won more matches against Udinese than any other Serie A opponent. It will be fascinating to see if they are all selected again for trickier tests in the future.
Ronaldo still going strong
The forward - who turns 35 in February - may not quite have the blistering pace that was once such a trademark, but he remains a ruthless finisher. His goals demonstrated just how dangerous he is when presented with a sight of the target.
Lasagna goes cold on big stage
The Italy international was starved of service in an opening half that was one-way traffic towards the Udinese goal. In the second, however, he failed to capitalise on the opportunities that came his way, including twice allowing recovering defenders to make crucial blocks when seemingly in the clear.
Juventus go up against Claudio Ranieri's Sampdoria on Wednesday in their final league outing before the mid-season break in Italy. Udinese, meanwhile, round out 2019 with a home game against Cagliari next Saturday.