Tennessee caused an upset when they shocked reigning champions the New England Patriots in the wild-card clash last week to earn a trip to the divisional round.
And the Titans – 9-7 in the regular season – defied the odds again with a sensational 28-12 victory away to Lamar Jackson's Ravens in Baltimore, where Derrick Henry starred on Saturday.
Coming off the bye week and a franchise-record 14-2 season, confidence was high within the Ravens camp, but the top seeds found themselves trailing from the outset.
Titans quarterback Ryan Tannehill, who finished seven of 14 for 88 yards and a pair of touchdowns to go with a rushing TD, and his 12-yard throw to Jonnu Smith with less than four minutes remaining in the opening quarter gave Tennessee a 7-0 lead.
Another Tannehill pass, this time a 45-yard throw to Kalif Raymond early in the second quarter, extended the Titans' lead amid silence in front of Ravens fans in Baltimore.
A pair of Justin Tucker field goals gave the Ravens their first points as they went into the half-time break trailing 14-6.
The Titans oozed confidence in the second half and a sequence of brilliance from running back Henry stretched Tennessee's advantage against Baltimore.
After his breathtaking 66-yard run, Henry put the Titans in the red zone and he capped the drive with a jump-pass touchdown throw to Corey Davis as back-up quarterback Marcus Mariota motioned out of the backfield.
Tannehill returned to the field moments later and rushed for a one-yard touchdown – the Titans ending the third period with a commanding 28-6 lead.
Frustrated, Ravens star Jackson – 31 of 59 for 365 yards, a touchdown, two interceptions and four sacks – gave Baltimore some hope with a TD pass to Hayden Hurst with just over 11 minutes remaining in the contest but the Titans were too good.