The Pelicans are 10th in the Western Conference standings with a 25-32 record, but still harbour hopes of claiming the eighth seed in the playoffs.
Should they achieve that goal, the Pelicans could face the Lakers, who hold the top seed in the West as it stands, in the first round of the postseason.
Williamson, though, is not viewing this week's encounter as a possible playoff preview.
"I'm not necessarily looking at it from that perspective," he told reporters after scoring 28 points in the Pelicans' 115-101 road win over the Golden State Warriors on Sunday.
"I'm looking at from the perspective as you know we need every win, we're trying to fight for that eighth seed in the playoffs."
On four-time MVP James, he added: "I used to watch him all the time, especially when he was in Cleveland the first time, he was just an incredible player to watch, he always held his own.
"Sometimes I feel he doesn't get the respect he deserves but it's not for me to decide."