Only needing a draw, Mexico secured automatic qualification to the 2022 World Cup with a 2-0 win over El Salvador on Wednesday.
Goals from Anthony Contreras and Juan Pablo Vargas secured the win over the USA, who still automatically qualified for the World Cup.
Needing a win to essentially secure their place at the World Cup, Mexico played a dominant second half away from home to beat Honduras 1-0.
The United States could lose 5-0 to Costa Rica on Wednesday and still reach the World Cup after all but sealing qualification.
After a 36-year absence, Canada are heading back to the World Cup, and coach John Herdman senses the start of something big.
England were beaten 2-1 by France in the World Cup quarter-finals last month, but Jude Bellingham is trying not to dwell on it.