Ramos was included in Robert Moreno's XI for a Euro 2020 qualifier away to Norway on Saturday, with qualification in their sights.
When he equalled Casillas' record last month, Ramos indicated he has a landmark appearance in mind before following former centre-back partner Gerard Pique into international retirement.
"Records are there to be broken," said the Real Madrid defender, who made his Spain debut in 2005.
"I hope that this momentum, enthusiasm and ambition always accompanies me and that I reach 200 games, which is the objective. You have to make it difficult."
🔝 @SergioRamos cumple hoy 168 partidos con nuestra camiseta y se convierte en el futbolista que más veces ha jugado con ella.— Selección Española de Fútbol (@SeFutbol) October 12, 2019
⭐ 1 Mundial
🏆🏆 2 Eurocopas
✌🏻 125 victorias
⚽ 21 goles
Aún nos queda mucho por vivir juntos.
🙌🏻ERES LEYENDA, CAPITÁN🙌🏻#RamosLeyenda pic.twitter.com/qkK0E9ct9O
Ramos is reportedly keen to play for Spain at the Olympic Games in Tokyo next year in a bid to add to the World Cup and European Championship titles he has won with La Roja.
Asked about the matter this week, Moreno told reporters: "I haven't talked about the Olympic Games with him. That desire defines him as a footballer.
"He has one more motivation to add to his career. It is difficult, when you have won everything, to stay motivated."