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The seventh seed came from behind to win 3-6 6-4 6-2 in two hours and nine minutes, setting up a round of 16 clash with Thiago Agustin Tirante.

Llamas Ruiz made a strong start in Rome, converting his very first break point in the opening game before clinching the first set with another break point in the ninth game.

Medvedev answered back in the second, with one converted break point enough for the Russian to force a deciding set in the Italian capital.

The Russian carried his momentum into the third as two early breaks saw him race into a 4-1 lead.

Llamas Ruiz replied with a break of his own, only for Medvedev to return the favour and go 5-2 up before serving out for the win.