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After a 1-1 draw in normal time, the Owls, whose off-field issues meant they only had one stand open for the fans amid protests, triumphed 3-0 in the shootout.

Seven of Wednesday's players have never made a league start for the club, but Leeds was unable to break down its resilient back line in the first half.

Karl Darlow's woeful mistake led to the opening goal 63 minutes in as he failed to hold onto Jamal Lowe’s arrowed cross, allowing it to trickle over the line, though substitute Jayden Bogle's low drive levelled the score in the 81st minute.

Debutant Dominic Calvert-Lewin then missed two glorious chances to win it, and Leeds' profligacy was punished in the shootout, as Ethan Horvath brilliantly saved Joel Piroe and Sean Longstaff's efforts on either side of Calvert-Lewin's skied effort.

Sunderland was another Premier League casualty as it was knocked out by League One Huddersfield Town.

Leo Castledine's ninth-minute opener was cancelled out by Marc Guiu with six minutes remaining, as the Black Cats finished normal time at 1-1.

However, Huddersfield triumphed 6-5 from 12 yards – after the first 11 players all netted its spot-kicks, Lee Nicholls proved the hero as he kept out Milan Aleksic.