Midfielder Florian Pick sealed a sensational win for third-tier Kaiserslautern with a 90th minute strike after Manfred Starke's penalty had given them the lead on 63 minutes.

"We lost our heads after we went behind," said Mainz midfielder Daniel Brosinski. 

Four-time German champions Kaiserslautern were not the only giant-killers on Saturday however, with fourth-tier side SC Verl humbling Bundesliga outfit Augsburg with a deserved 2-1 win.

Augsburg's defence looked helpless in the first half as an own-goal from Marek Suchy and a well-worked goal from Ron Schallenberg gave Verl a shock 2-0 lead. 

Andre Hahn's 83rd minute penalty proved to be little more than a consolation effort.

"Verl deserved to win and we have a lot of work to do before we play Dortmund next weekend," said Augsburg coach Martin Schmidt.

Elsewhere, Fortuna Duesseldorf came from behind to survive a scare against fifth-tier side Villingen.

Rouwen Hennings and 18-year-old Ghanaian Kevin Ofori sealed the win in extra-time for Duesseldorf after Nana Ampomah had cancelled out Steven Ukoh's first-half penalty.

Hoffenheim also had a narrow escape after twice throwing away the lead against third-division club Wuerzburger Kickers.

Goals from Ihlas Bebou and Pawel Kaderabek left Hoffenheim with one foot in the second round before two goals in seven minutes from Fabio Kaufmann and Albion Vrenezi brought Wuerzburg level. 

Adam Szalai restored Hoffenheim's lead in extra-time, only for Luca Pfeiffer to make it 3-3 with a late header.

The underdogs finally succumbed in the penalty shootout, Oliver Baumann saving twice to send Hoffenheim into the second round. 

- Schalke fans protest -                  
Schalke fans used their 5-0 victory over Drochtersen/Assel to protest against chairman Clemens Toennies, who has temporarily stepped down over a racism scandal earlier this month. 

Supporters held up banners reading "Toennies out" before watching their side cruise into the second round thanks to goals from Steven Skrzybski, Guido Burgstaller, Munir Mercan and Daniel Caligiuri.

Bayer Leverkusen also progressed, beating fourth-tier Alemannia Aachen 4-1, Peter Hackenberg's own-goal and strikes from Kevin Volland, Leon Bailey and Kai Havertz saw Leverkusen sail into the next round.

An extra-time goal from Luca Waldschmidt saw Freiburg beat third-tier Magdeburg, while a Claudio Pizarro brace helped Werder Bremen thrash amateur neighbours Atlas Delmenhorst 6-1.

Tom Schmidt, a bank clerk who sells self-printed t-shirts on the internet, made Delmenhorst club history with his first half strike, but goals from Pizarro, Yuya Osako, Niklas Moisander, Milot Rashica and Davy Klaassen saw Werder to a victory.

Second division sides Dynamo Dresden, Heidenheim, Bochum, Erzgebirge Aue and Arminia Bielefeld all knocked out lower league opposition.