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Facundo Farías opened the scoring on 28 minutes after a calamitous mix-up between goalkeeper Pedro Díaz and defender Aldair Fuentes left the ball gift-wrapped.

Cusco's response was immediate, Lucas Colitto producing a brilliant finish to level the scores on 30 minutes.

The tie turned early in the second half. Colitto received a second yellow card just five minutes after the restart, leaving the Peruvian side a man down.

Estudiantes capitalised swiftly, with Tiago Palacios drilling home a composed left-footed strike from outside the area on 48 minutes to seal the win.

Estudiantes tops Group A with four points, while Cusco sits bottom without a point after two matches.