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Just eight minutes into the match, Marchesín suffered a serious-looking knee injury and was forced off in tears, with Leandro Brey taking his place.

Despite the disruption, the Xeneizes controlled proceedings.

Lautaro Di Lollo broke the deadlock on 39 minutes to send La Bombonera in ahead at half-time.

Santiago Ascacíbar headed home a superb Lautaro Blanco cross on 81 minutes to double the advantage, before Ander Herrera wrapped up a comfortable 3-0 victory deep into stoppage-time with a shot from outside the box.

Barcelona SC, which also lost its opener to Cruzeiro, now sits bottom of the group with zero points, facing a must-win home game against Universidad Catolica on 30 April (AEST).