Osaka, who won the most recent of her four grand slam titles last year at Melbourne Park, has looked in fine form this week in her first appearances since returning from the break she took from tennis last year.
The No.1 seed beat Alize Cornet, Maryna Zanevska and Andrea Petkovic en route to the semi-finals, but could not compete against Veronika Kudermetova on Saturday, citing an abdominal injury.
Osaka explained that her body had taken a hit from playing such intense matches in consecutive days, and she instead is looking to rest and recover ahead of the first grand slam of the season, which starts on 17 January.
"Sad to withdraw due to injury from my match today, my body got a shock from playing back to back intense matches after the break I took," Osaka tweeted.
Sad to withdraw due to injury from my match today, my body got a shock from playing back to back intense matches after the break I took. Thank you for all the love this past week ❤️ I’ll try to rest up and I’ll see you soon!— NaomiOsaka大坂なおみ (@naomiosaka) January 8, 2022
"Thank you for all the love this past week [Red heart] I’ll try to rest up and I’ll see you soon!"
Osaka's injury has prevented what looked to be an enticing showdown with Simona Halep, who guaranteed a place in a WTA Tour singles final for a 13th successive season by beating Chinese teenager Zheng Qinwen 6-3 6-2.
Halep's first final came in 2010 and she has taken just a week to get back into her stride after an injury-ravaged 2021 season.
The Romanian, a two-time grand slam champion, went into the week ranked at world number 20, her lowest position at the start of a season since 2013.
However, she has now reached at least the semi-final stage in three successive tournaments, and she will fancy her chances against No.3 seed Kudermetova, who is into her third singles final.