Brazil is nine points clear at the top of the standings with four matches to go and are the only South American nation assured of its place in Russia so far.

Tite had hinted at selecting an increased number of domestic-based players but has opted to name a strong squad for the fixtures, with Neymar set for a playing return to his home country for the first time since completing a world-record $A331 million transfer from Barcelona to Paris Saint-Germain.

Commenting on Neymar's move, Tite said: "He is looking for a new challenge, a new club and career plan.

"The essence is to enjoy football. Two items are fundamental: the supporters and the player.

"Allow him to be happy in his club, to adapt and develop to his best."

Neymar is joined in the front line by Gabriel Jesus, Roberto Firmino and Taison, while Liverpool attacker Philippe Coutinho is also included.

David Luiz and Douglas Costa are two of the biggest names to be left out of the squad, but uncapped Manchester City goalkeeper Ederson will hope to make an impression.

Brazil squad in full:

Goalkeepers: Alisson, Cassio, Ederson.

Defenders: Dani Alves, Rodrigo Caio, Fagner, Filipe Luis, Marcelo, Marquinhos, Miranda, Thiago Silva.

Midfielders: Renato Augusto, Casemiro, Philippe Coutinho, Fernandinho, Giuliano, Luan, Paulinho, Willian. 

Forwards: Roberto Firmino, Gabriel Jesus, Neymar, Taison.