Third-placed Fulham was held 1-1 by Derby County on Saturday (AEDT) and Brentford, in fourth, played out a 2-2 draw with Blackburn Rovers.
Nottingham Forest and Bristol City also dropped points, drawing 0-0 with Queens Park Rangers and losing 3-0 to leader West Bromwich Albion respectively, with the Baggies maintaining their four-point gap on Leeds.
Elsewhere, Wigan Athletic and Barnsley picked up wins to boost their survival hopes.
LEEDS, WEST BROM PULLING AWAY
Pablo Hernandez's 57th-minute strike earned Leeds back-to-back 1-0 home wins.
West Brom appears over its mid-season wobble after making it four wins in five matches with a comfortable victory.
Callum Robinson put Slaven Bilic's side on course for an 11th away win of the campaign with a fortuitous opener and Hal Robson-Kanu netted twice, either side of Romaine Sawyers' straight red for grabbing Jamie Paterson by the throat.
CHASING PACK FALTER
Brentford fought from two goals down to draw 2-2 with Blackburn as it joined west London rival Fulham in dropping points.
Ollie Watkins scored an impressive volley and Said Benrahma netted from the penalty spot to cancel out Adam Armstrong's double.
Forest missed out on the chance to move up to third after failing to break down QPR in a stalemate at City Ground, while Preston North End recovered from a goal down to beat Hull City 2-1.
HOPE FOR WIGAN, BARNSLEY
Shaun Hutchinson's own goal was enough for Wigan to earn just an eighth league win of the campaign at home to Millwall, while Barnsley built on its shock 3-0 win at Fulham last weekend with a 1-0 victory over Middlesbrough.
Wigan and Barnsley are now two and five points adrift of 21st-placed Huddersfield Town respectively after the Terriers' 3-1 defeat at Swansea City.
Luton Town is now occupying bottom place, with Lyle Taylor's double earning Charlton Athletic a 3-1 win.
Elsewhere, a Callum Paterson own goal and a scrambled finish from Joe Allen saw Stoke City earn a 2-0 home win against Cardiff City that leaves it three points clear of the drop zone.
SIX-GOAL THRILLER AT ST ANDREW'S
Birmingham City and Sheffield Wednesday remain locked on 45 points after a frantic 3-3 draw.
Garry Monk was denied a winning return to one of his former clubs by Scott Hogan's equaliser in stoppage-time, the Aston Villa loanee's fourth goal in five matches.
Wednesday had twice battled back from a goal down before Jacob Murphy put it in front, but it is now winless in six outings.