Manchester United's scheduled Europa League trip to Real Sociedad will now take place on neutral ground in Turin.
Ole Gunnar Solskjaer's side were set to head to San Sebastian for the round-of-32 clash on February 18.
However, the match has been moved from the Anoeta to Juventus' Allianz Stadium due to Spanish government restrictions on travellers entering the country from the United Kingdom in relation to the new COVID-19 variant.
The match will still kick off at 18:55 CET, with the February 25 return leg at Old Trafford due to go ahead as planned.
Both matches will take place behind closed doors.
"UEFA would like to thank Real Sociedad and Manchester United for their close co-operation and assistance in finding a solution to the issue at hand, as well as the Italian Football Federation and Juventus for their support and agreeing to host the match in question," read a statement issued by European football's governing body.
Similar rules in Germany have led to Manchester City and Liverpool's Champions League last-16 away games against Borussia Monchengladbach and RB Leipzig respectively being moved to Budapest.