Ben Moon and Jack Nowell have been named in the starting line-up for England's crunch Six Nations clash with Wales in Cardiff on Saturday.
Moon gets the nod after influential prop Mako Vunipola suffered a tournament-ending ankle injury in the thrashing of France last time out.
Nowell will be back on the right wing at the Principality Stadium in the absence of Chris Ashton, who misses out due to a calf strain.
Joe Cokanasiga, Brad Shields, Ellis Genge and Harry Williams have been named among the replacements as both sides look to make it three wins out of three.
England head coach Eddie Jones said: "England and Wales is always a big game.
"Intense rivals and there is the historical context to it, but for us it is our most important game because it is our next game and that is how we are treating it.
"As you have read in the media, it's all about Wales, we are playing potentially the greatest team ever. Their players are full of emotion and it's the biggest game they are going to play in their lives.
"We have had a good week just focusing on ourselves and focusing on getting our preparation right."
England: Elliot Daly, Jack Nowell, Henry Slade, Manu Tuilagi, Jonny May, Owen Farrell (captain), Ben Youngs; Ben Moon, Jamie George, Kyle Sinckler, Courtney Lawes, George Kruis, Mark Wilson, Tom Curry, Billy Vunipola.
Replacements: Luke Cowan-Dickie, Ellis Genge, Harry Williams, Joe Launchbury, Brad Shields, Dan Robson, George Ford, Joe Cokanasiga.