Brooklyn Nets head coach Steve Nash said securing the Eastern Conference's number one seed would be "valuable" but not at the expense of losing players to injury as his short-handed team lost the top spot to rivals the Philadelphia 76ers.

The star-studded Nets (37-18) were without Kevin Durant, James Harden, LaMarcus Aldridge and Blake Griffin for Wednesday's 123-117 defeat away to fellow NBA championship hopefuls the 76ers (38-17).

After posting 31 points in 27 minutes against the Minnesota Timberwolves on Tuesday – just his third appearance since a 23-game injury absence – the Nets opted to sit former MVP Durant and avoid back-to-back outings.

Despite missing most of their stars, though Kyrie Irving (37 points) returned, the Nets almost upstaged the 76ers in the highly anticipated showdown, rallying from 22 points down to close within 118-115 with just over one minute remaining.

"It'd be great to have the number one seed. I think it means a lot, it's valuable," Nash said afterwards. "But not at the expense of losing players or prolonging our injury situation.

"So I think we have to be very careful and make sure that our guys get to the finish line as whole as possible."

Durant has been averaging 28.2 points, 7.1 rebounds and 5.2 assists per game this season.

He is also shooting a career-high 44.8 per cent from three-point range, while the two-time NBA champion (53.5) only boasted a better field-goal percentage in 2016-17 (53.7).

On Durant's absence, Nash responded to suggestions the two-time NBA champion was held out to keep Philadelphia guessing to how Brooklyn – eyeing a maiden title – might operate as a full and healthy unit in the playoffs.

"I think when you start to really try to be cute, it backfires most of the time," Nash said. "It wasn't strategic. It was, this is what this is the availability we have."

Irving – who returned from a personal issue after sitting out the Timberwolves matchup – starred for the Nets, but he watched from the sidelines as Brooklyn's reserves rallied down the stretch.

"Just played their hearts out," Irving said. "That's all you can ask coming out here to play the game that we all love. Just to go out there and compete. You know I'm sure they were chomping at the bit.

"Especially to get that win down the stretch for us and I feel like they grew as a group, we grew as a team and they learned some things out there playing against a high level playoff team that we can potentially see down the line. So it was a fun game overall."