Juventus forward Paulo Dybala has been ruled out of Argentina's squad for their upcoming World Cup qualifiers.
The 26-year-old was brought on as a substitute for the final 14 minutes of Juve's 1-1 draw with Lazio on Sunday but is deemed unfit to team up with his national side.
He missed Argentina's opening two qualifiers in October - victories over Ecuador and Bolivia - and will now play no part against Paraguay and Peru over the next fortnight.
Argentina confirmed in a statement on Sunday that Dybala is "presenting general genitourinary symptoms which require rest and evaluations".
Dybala has made six appearances for Juventus in all competitions this season and scored his only goal in last week's 4-1 Champions League win over Ferencvaros.
Ajax defender Lisandro Lopez has been added to Lionel Scaloni's 25-man squad, which also includes the likes of Lionel Messi and Angel Di Maria.