Wednesday's results left all three teams on 10 points but Flamengo (+6) and LDU Quito (+4) pipped Penarol (+2) on goal difference.
Gremio only have one point from three Group H fixtures following Thursday's 1-0 loss away to Universidad Catolica.
River Plate won a fourth Copa Libertadores title as two extra-time goals saw them come from behind to beat Boca Juniors 3-1 in Madrid.
River Plate facing Boca Juniors in Madrid is a footballing occasion uprooted from a proud history and could have far-reaching consequences.
CONMEBOL rejected Boca Juniors' appeal against River Plate's Copa Libertadores punishment, meaning Sunday's final second leg will go ahead.
Paris Saint-Germain's Dani Alves took to social media to voice his anger at the decision to play the Copa Libertadores final in Madrid.
Genoa offered River Plate and Boca Juniors on Monday the opportunity to play the second leg of the postponed Copa Libertadores final in the Italian city .
The decision to suspend the Copa Libertadores final until Sunday has been backed by the presidents of Boca Juniors and River Plate.
All eyes will be on Buenos Aires on Saturday as River Plate host Boca Juniors in the Copa Libertadores final second leg.
The Copa Libertadores final first leg ended in a 2-2 draw between Boca Juniors and River Plate after an enthralling clash at La Bombonera.
The first leg of the Copa Libertadores final between Boca Juniors and River Plate has been postponed due to a waterlogged pitch.
Ahead of the first leg of the Copa Libertadores final between Boca Juniors and River Plate, we look at where the rivalry started.
A 2-2 draw against Palmeiras was enough for Boca Juniors to set up a Copa Libertadores final against River Plate.
The ICC say their investigation does not relate to the upcoming series between Sri Lanka and England.
River Plate and Gremio will meet in the final four after respective wins against Independiente and Atletico Tucuman.
Cruzeiro will not have to play the second leg of their Copa Libertadores quarter-final against Boca Juniors without Dede.
Carlos Tevez was on target as Argentine powerhouse Boca Juniors progressed 6-2 on aggregate thanks to Thursday's 4-2 victory.
River Plate were too good for Racing Club to move into the quarter-finals of the Copa Libertadores.
Independiente were awarded a 3-0 victory just hours before Tuesday's return fixture after Santos fielded an ineligible player.
Miguel Borja scored a second-half brace away from home in Asuncion to put Palmeiras in a strong position on Thursday.
Copa Libertadores holders Gremio suffered a narrow 2-1 loss away to 10-man Estudiantes in the round-of-16 first leg on Tuesday.
Lucas Pratto led River Plate past Santa Fe and into the last 16 of the Copa Libertadores.
Former Benfica striker Oscar Cardozo was the hero, his 90th-minute free-kick preserving Libertad's 100 per cent record in Group Three.
Cicero was the hero for Gremio, coming off the bench to score an 83rd-minute winner against Lanus on Wednesday.
Barcelona won 1-0 on Wednesday but Gremio still progressed to the Copa Libertadores final 3-1 on aggregate.
Brazilian sides Atletico Mineiro and Palmeiras came unstuck against Wilstermann and Barcelona in the last 16 of the Copa Libertadores.
2015 champions River Plate triumphed 2-0 at Paraguayan hosts Guarani in the first knockout round of the Copa Libertadores.
Estudiantes were 3-0 winners at Barcelona but Botafogo's victory saw Juan Sebastian Veron's men eliminated.
Atletico Tucuman beat El Nacional 1-0 to reach the third qualifying phase of the Copa Libertadores - no mean feat given their travel woes.
Atletico Nacional sealed a Copa Libertadores final place thanks to a double from Miguel Borja.
Ulsan came from behind to beat Urawa Red Diamonds 2-1, while Shanghai SIPG were held to a 1-1 draw by Jeonbuk Hyundai Motors.
Kashima Antlers' AFC Champions League defence continued after they did just enough to progress, as did Guangzhou Evergrande.
Shanghai SIPG are into the knockout stages of the AFC Champions League, as are Urawa Reds after a crucial win over Beijing Guoan.
Xavi's playing days have come to a close after the Spain icon featured for the last time in Al Sadd's defeat to Persepolis in Iran.
The pots are set for the last 16, with the draw scheduled to take place in Paraguay on Monday.
Former Barcelona star Xavi rolled back the years by scoring a brilliant free-kick in Al Sadd's AFC Champions League win over Pakhtakor.