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Injury-hit Napoli, missing key players including Kevin De Bruyne and Romelu Lukaku, controlled possession and created chances in the first half but failed to find the breakthrough.

Francesco Camarda could have put Lecce ahead from the penalty spot just before the hour mark after a handball by Juan Jesus, but Napoli keeper Vanja Milinkovic-Savic saved his attempt.

Zambo Anguissa broke the deadlock in the 69th minute, glancing a free kick into the far top corner to give Napoli the three points.

With the win Napoli moved clear at the Serie A summit with 21 points, three ahead of AS Roma, which plays Parma on Thursday.