The Manchester United forward was a second-half substitute in Eindhoven and applied the decisive touch with a tap-in from Tijjani Reijnders' cross.
The Netherlands beat Serbia 2-1 thanks to Joshua Zirkzee's winner to move top of their Nations League group
The match also marked Virgil van Dijk's 100th international appearance.
New Netherlands coach Xavi is unbeaten after four games, with two wins and two draws.
