Their final league game away at Real Sociedad on Sunday is not only must win, but they require favours from a whole host of clubs above them. Despite massive improvement at the Ramon Sanchez Pizjuan, where they have only lost twice under their new coach, Sevilla will likely miss out on European qualification through the league for the first time in a decade.
For Roma, a top-four finish evaporated in Florence at the weekend. Tammy Abraham has not been so prolific this season. Roma's goalless draw with Bayer Leverkusen in the second leg of their semi-final was hardly an eye-catching watch, but it further cemented Mourinho's status as a master tactician. The club's defensive consistency has been strong throughout, and one wonders whether Mourinho will set his side up to soak up Sevilla's pressure and hit them on the counter.
Likely Team Line-ups
Sevilla: Bounou; Navas, Bade, Gudelj, Telles; Fernando, Rakitic; Ocampos, Torres, Gil; En-Nesyri
Roma: Patricio; Mancini, Smalling, Ibanez; Celik, Cristante, Matic, Spinazzola; Dybala, Pellegrini; Abraham
The lucrative prize of UEFA Champions League football next season is available for the winner.
Something will have to give at the Puskas Arena as defeat will not only end that opportunity, but it will also end either Sevilla's extraordinary run of Europa League victories or Mourinho's equally impressive record in never losing a final on the continent.
Sevilla will start as start favourites, but the special one will have plenty to say about that come kick-off. You can catch all the live and exclusive action on beIN SPORTS English 1 on Wednesday, 31st May.
Coverage begins at 21:00 Mecca time. Aarran Summers will be joined by Jason McAteer and Nick Summerbee.