Yunus Akgun fired the visitors ahead shortly after kickoff, but Soriba Diaoune equalised five minutes later and struck again in the 39th minute to put Lille in front.
Galatasaray beat Lille 4-2 in UEFA Champions League after twice surrendering the initiative
Alexey Batrakov headed Galatasaray level in the 44th minute before Lucas Torreira appeared to glance home a corner in the 52nd, although the effort was later credited as an own goal for Nabil Bentaleb.
Victor Osimhen completed the scoring nine minutes later with a powerful strike from the edge of the box.
