Holders Athletic Bilbao welcome Osasuna while Spanish champions Real Madrid host Celta Vigo.
Barcelona to face Betis in Copa del Rey last 16
Record 31-time Copa del Rey winners Barcelona were drawn at home against Real Betis in the last 16 on Wednesday.
Diego Simeone's Atletico Madrid visit second-division Elche, while fourth-tier Pontevedra, the lowest ranked side left in the competition, host La Liga team Getafe.
The matches will take place between January 14-16.
Full draw:
Pontevedra v Getafe, Ourense v Valencia, Almeria v Leganes, Elche v Atletico Madrid, Real Madrid v Celta Vigo, Barcelona v Real Betis, Real Sociedad v Rayo Vallecano, Athletic Bilbao v Osasuna.
