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Macclesfield stunned the holder at the weekend, winning 2-1 to cause arguably the biggest upset in FA Cup history.

It marked the first time a sixth-tier team had defeated a top-flight side in the competition, but Macclesfield will now get the chance to repeat the trick on the weekend of 15-16 February (AEDT).

Brentford, which is flying high in fifth in the Premier League, overcame Sheffield Wednesday 2-0 in its third-round tie.

Arsenal has been drawn against 2013 FA Cup winner Wigan Athletic, while Manchester City will take on Salford City, which is part-owned by famous faces from Manchester United's past, or Swindon Town.

Chelsea will head to Hull City, making for a reunion with his former club for new Blues boss Liam Rosenior, while Liverpool will host Brighton and Hove Albion after beating Barnsley 4-1 at Anfield.

Aston Villa and Newcastle United go head-to-head in an all Premier League tie, and Leeds United must go up against Birmingham City.

Mansfield Town beat Sheffield United 4-3, and its reward is a clash with Burnley at Turf Moor.

FA Cup fourth round draw in full:

Liverpool or Barnsley v Brighton & Hove Albion
Stoke City v Fulham
Oxford United v Sunderland
Southampton v Leicester City
Wrexham v Ipswich Town
Arsenal v Wigan Athletic
Hull City v Chelsea
Burton Albion v West Ham United
Burnley v Mansfield Town
Norwich City v West Bromwich Albion
Port Vale v Bristol City
Grimsby Town v Wolverhampton Wanderers
Aston Villa v Newcastle United
Manchester City v Salford City or Swindon Town
Macclesfield v Brentford
Birmingham City v Leeds United