Front two Federico Chiesa and Dusan Vlahovic scored in the early part of the second half to break open a previously underwhelming encounter at the Allianz Stadium in Turin.

The two sides also met in Serie A on Saturday, Lazio winning that game 1-0 with a stoppage-time goal from Adam Marusic, but Massimiliano Allegri’s side successfully turned the tables as he chases a record fifth Coppa Italia as coach to break a tie with Roberto Mancini and Sven-Goran Eriksson.

Lazio lost Mattia Zaccagni to injury just 10 minutes in after he was caught by Federico Gatti – and were grateful things did not get worse even before substitute Gustav Isaksen was able to enter the pitch.

Matias Vecino was harshly penalised after catching Andrea Cambiaso in his own area, the Juventus player leaping across him as he cleared the ball, but VAR overruled the penalty decision due to Cambiaso being offside when Vlahovic headed towards goal.

Isaksen saw one long-range effort blocked and another deflected behind by Danilo for a corner and Felipe Anderson ripped a 25-yard drive well over.

Cambiaso failed to control a deft return ball from Chiesa, costing Juve one of their few clear sights of goal in the first half, and they will be without defender Gatti for April 23’s return leg due to suspension after he was booked for a foul on Isaksen.

Luis Alberto headed Patric’s cross against the bar, with keeper Mattia Perin a touch uncertain under the looping ball, and Adrien Rabiot’s powerful 20-yard volley was straight at Christos Mandas in the Lazio goal as the half ended scoreless.

Nicolo Casale replaced Patric at half-time but the visitors soon fell behind when Manuel Locatelli did well to keep the ball alive and Cambiaso’s brilliant long pass cut the Lazio midfield and defence out of the game for Chiesa to finish clinically.

Locatelli blasted just wide after a rapid break, though a free-kick was given against Chiesa in any case, but Vlahovic soon made it 2-0 after turning Casale inside out.

Gatti headed just wide from Filip Kostic’s corner, conceded by Casale’s excellent tackle as Chiesa appealed in vain for a penalty, before Lazio boss Igor Tudor sought to change things with the introductions of Taty Castellanos and Daichi Kamada.

Juve substitutes Kenan Yildiz and Timothy Weah combined with Vlahovic to create a chance that was snuffed out by Mandas and Yildiz fired an ambitious effort well wide in the closing stages.