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Osaka withdrew from the French Open having won her first-round match, after she was fined and threatened with further punishment – and possible expulsion from the grand slam – for skipping obligatory media duties.
The four-time grand slam champion had confirmed before Roland Garros that she would not be taking part in post-match news conferences, suggesting her mental health was not helped by having to attend the mandatory interviews.
Osaka, the world number two, stated she has had "long bouts of depression" since winning the 2018 US Open title.
With Wimbledon starting at the end of June, Osaka has decided to skip the third grand slam of the year, and instead take time away from tennis.
However, she aims to be back to represent Japan in their home Olympic Games, which start next month.
A statement from Osaka's representatives confirmed that she will miss Wimbledon while taking some personal time with friends and family, but that she will be ready for the Olympics.
The 23-year-old's withdrawal came on the same day that Rafael Nadal – a beaten semi-finalist at Roland Garros – confirmed he would not play at Wimbledon or the Olympics.
Nadal, 35, explained that the quick turnaround from a gruelling campaign in Paris to another tough schedule at Wimbledon presented too much of a risk to his fitness.