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World number three and two-time grand slam winner Halep last month withdrew from the French Open after sustaining a calf injury.
The Romanian is targeting a return in time for the grass-court swing and will feature at the new WTA 250 event in Germany.
Designed with preparation for Wimbledon in mind, the Bad Homburg Open will run from June 20-26.
Halep, who has accepted a wildcard, is one of three former Wimbledon winners to be participating, alongside Angelique Kerber and Petra Kvitova.
"I have some good news to share with you," Halep said in a video posted to her official Twitter account.
"I am super excited to announce that I will be playing for the first edition in Bad Homburg and I am looking forward to seeing all of the fans in the stands."
Halep, who has also triumphed at Roland Garros, overcame Serena Williams 6-2 6-2 in the 2019 Wimbledon final.
The grand slam in London did not take place last year due to the coronavirus pandemic.