United handed a daunting path in UEL draw
Manchester United must overcome UEFA Europa League specialist Sevilla in order to reach a semi-final against either Juventus or Sporting CP.
United defeated Real Betis in the Round of 16 and will now face its city rival Sevilla, six-time winner of the competition.
The sides have met three times previously, with Sevilla knocking United out of the 2017-2018 UEFA Champions League over a two-legged tie before beating the Red Devils again in a one-off 2019-2020 UEFA Europa League semi-final.
It is a daunting draw for United, which could then have to play Juventus in the last four.
The semi-final draw paired the winners of United's tie with Juventus or Sporting, the latter having eliminated Arsenal on Friday (AEDT) via a penalty shootout.
Even in the final, should Erik ten Hag's men make it that far, United could be set for a reunion with former manager Jose Mourinho.
Mourinho's Roma was drawn against Feyenoord in the quarter-finals in a repeat of last season's UEFA Europa Conference League final, which the Giallorossi won.
Bayer Leverkusen meets Union Saint-Gilloise in the last-eight tie, playing for the right to face Roma or Feyenoord.
UEFA Europa League quarter-final draw in full:
Manchester United v Sevilla
Juventus v Sporting CP
Bayer Leverkusen v Union Saint-Gilloise
Feyenoord v Roma