The Serie A leader needed to at least match Borussia Dortmund's result against Slavia Prague due to being level on seven points before the game, but the Germans emerged 2-1 victors to secure their progression as Inter were made to rue their own wasteful finishing.
After weathering an early Inter storm, a much-changed Barca went ahead through fringe forward Carles Perez, though its lead did not last – Romelu Lukaku blasting in from 20 yards.
Lukaku was otherwise wasteful in front of goal, however, missing a particularly fine opportunity early in the second period, before the visitors sealed Inter's fate late on through 17-year-old Fati, dropping the Italians into the Europa League.
