The returning Anthony Watson set England on its way to a 33-30 win at home to Wales that keeps its Six Nations title challenge on track.

With Grand Slam contender France not in action against Scotland until Monday (AEDT), Eddie Jones's England piled on the pressure with a hard-fought triumph at Twickenham.

The host was boosted by the inclusion of wing Watson in the XV for the first time in the tournament, and he got the first of three England tries.

Elliot Daly crossed later in the first half and, after Justin Tipuric raced through for Wales at the start of the second period, Manu Tuilagi secured a third win in four matches for England before being sent off with five minutes remaining. Dan Biggar and Tipuric grabbed consolation tries for Wales in the closing moments, earning them a losing bonus point.

It took Watson less than four minutes to make his mark, dancing through a pair of tackles after a smart move from a lineout on the right to score the opening points.

An eventful start continued as Jonny May departed with a head injury before a scuffle broke out in front of the England try line, prompting a penalty against Owen Farrell that Leigh Halfpenny dispatched over the posts.

Farrell and Halfpenny traded further successful trips to the kicking tee as the match settled slightly, but a spell of England pressure resulted in their second try after 32 minutes as the hosts worked the ball from right to left and Daly steamed up the outside to lunge over.

Another Farrell penalty stretched England's lead again, only for some sloppy play to allow Biggar to boot a response heading into half-time.

And Wales came out for the restart with renewed vigour, scoring inside 30 seconds through a stunning counter that sent Tipuric clear under the posts.

But England continued to forge opportunities for their kickers, with Farrell adding three more points before George Ford assumed the responsibilities - his captain struggling with a dead leg - and followed suit.

Successive scores seemed to dampen Wales' spirits, and a patient England move made space for Tuilagi to walk in on the left.

A slew of late penalties against England resulted in a yellow card for Ellis Genge, and Tuilagi departed for a shoulder charge to George North's head.

That allowed first Biggar and then Tipuric to score against 13 scrambling white shirts, but the late tries proved only enough to rescue the bonus point.