Fabio Lucioni's first-half dismissal left lowly Lecce, which had started brightly, facing a daunting task yet it needed a moment of brilliance from Dybala to open the scoring after 53 minutes.
⚽️ GOAL!! 😲 #coronavirus may have got to @PauDybala_JR, but it's done nothing to dull his sense for goal!! Brilliant strike!!@juventusfc 1️⃣-0️⃣ @OfficialUSLecce— beIN SPORTS (@beINSPORTS_AUS) June 26, 2020
Watch LIVE on CONNECT @kayosports, @Foxtel & Fetch!! ▶️ https://t.co/2Cq0ULG8ym#SerieA | #JuventusLecce pic.twitter.com/richGqAGUB
Ronaldo and Federico Bernardeschi were guilty of woeful misses in the opening period but the former lashed home his 23rd Serie A goal of the campaign from the penalty spot before excellently setting up Higuain.
Matthijs de Ligt added a fourth that was harsh on Lecce as Maurizio Sarri's men stretched their lead on Lazio, beaten 3-2 by Atalanta last time out, albeit their rivals have a game in hand.
Andrea Rispoli flashed wide on the half-volley as Juve was carved open after four minutes.
Gabriel parried Adrien Rabiot's long-range shot and Ronaldo drilled wide of the right post as Juventus came to life and soon found itself a man up.
Rodrigo Bentancur caught Lucioni in possession 40 yards from goal and the centre-back chopped down his opponent to earn the straight red.
Ronaldo incredibly put a close-range header from Dybala's corner over the top when unmarked then teed up Bernardeschi, who missed an even bigger sitter when blazing high from inside the six-yard box.
Gabriel was in action again to keep out Leonardo Bonucci's header just after the restart but was powerless to stop Dybala opening the scoring.
Evgen Shakhov's careless pass was picked up by Ronaldo, who teed up the Argentina forward to curl a sumptuous left-foot effort into the top-right corner from the edge of the area.
It was game over just after the hour when Ronaldo lashed home the penalty he won after being tripped by Luca Rossettini.
The Portugal superstar would have had another had Gabriel not kept out his point-blank header but his ingenious backheel after a fine run deflected into the path of Higuain, who drilled home the third.
De Ligt then nodded in Douglas Costa's corner as Juve ultimately ran out a comfortable winner.