Those Wednesday fixtures, the first of the 92 remaining in a season that has been interrupted by the coronavirus pandemic, represent games in hand for the four teams involved..
Once completed, each of the 20 Premier League clubs will have played 29 games.
A full round of matches will then take place the next weekend, as Liverpool, with a 25-point lead at the top, aims to secure its first top-flight title in 30 years.
The Premier League hopes to complete the campaign by or on 2 August, with the FA Cup final potentially taking place the weekend after.
No matches have been played in the Premier League since 9 March because of the COVID-19 outbreak, which caused the suspension of sport across the globe.
A total of 12 people have tested positive for coronavirus after 2,752 tests across the league.
However, with teams having returned to contact training this week, the Premier League – after a shareholders meeting on Thursday – is poised to confirm a restart date for the competition.
LaLiga has been granted permission to restart in the week commencing 8 June, while Serie A clubs have been given a date of 20 June for a resumption of their league.