LaLiga has proposed moving the match to the Santiago Bernabeu amid the political unrest in Catalonia, and a reported alternative would be to set the fixture back to December.
Nine Catalan political leaders were given prison sentences ranging from nine to 13 years on Monday for their roles in the region's 2017 referendum and subsequent unilateral declaration of independence.
The ruling sparked a huge backlash and clashes between police and protestors, with Barcelona's main airport briefly closed the following day due to the tension.
A city rally has been called by pro-independence politicians for October 26, the day Barca are due to host their bitter rivals at Camp Nou.
There are concerns the match could be hijacked by protesters for political purposes, but Valverde was adamant Barca want it to be played on its intended date, at their home stadium.
He said in a news conference on Thursday: "There has been a lot of chatter about that game. There was the possibility of changing the order of matches and playing the game at Madrid first, but we don't see that.
"We have an away game this weekend, then [we would have another] next weekend, and then we have to go travel again. And not just because of that, but it's about respecting the calendar and the fans, and the normal thing is to play at our pitch, but we'll see what happens.
"People are getting a bit ahead of themselves with regard to this game. This has been a strange week in Barcelona, everyone knows that, but there's time still and we trust the game will be played in our stadium, which is what we want.
"There are nine days left before we play. We also played at the Wanda Metropolitano against Atletico Madrid [in 2017, after the Catalan independence referendum] and everyone said there would be drama and there was our fans, their fans – everyone has a right to express an opinion in the ground and we think the same thing will happen here.
"Everybody's thinking about whether the game's going to be moved, and it's an opportunity to show there is respect for your opponents that it can be played, and it's an important match for people to see.
"It should be played under normal circumstances. People can express their opinions in the stadium in a natural way."
Amid a suggestion a decision on the fixture could be taken as early as this Thursday by league officials, Valverde was asked whether a postponement might most help Barca or Madrid.
"I don't know, we're going to wait and see," he said. "We'd be coming off a Wednesday [game] and they off a Tuesday [game]. It could seem we benefit more by not having to play, but those things are not very important.
"These games are so highly anticipated that I think the players are ready to play them whenever they are played."