Stefano Sensi scored the winner as Inter required extra-time to edge past Empoli 3-2 in the Coppa Italia last 16 on Thursday (AEDT).

Alexis Sanchez opened the scoring after just 12 minutes at the San Siro, but Empoli turned things around as substitute Nedim Bajrami equalised before the visitors fortuitously took the lead when Ionut Radu deflected into his own net.

Andrea Ranocchia produced an acrobatic stoppage-time equaliser to send the tie to extra-time and substitute Sensi delivered the decisive strike after 104 minutes. 

Victory meant Simone Inzaghi's Serie A leaders squirmed through to the quarter-finals for the 18th time in 19 seasons.

Inter deservedly took the lead when Sanchez nodded Denzel Dumfries' cross into the bottom-left corner - the forward's second goal in the competition, 4,291 days after his first for Udinese in 2010.

The same pair combined eight minutes later, but Dumfries saw his effort kept out by Jacopo Furlan before a fantastic double save from the Empoli goalkeeper denied Lautaro Martinez.

Ranocchia should have doubled the lead immediately after the interval but wastefully headed over.

Bajrami punished Ranocchia's miss as he placed a left-footed effort into the bottom-right corner after Kristjan Asllani's offload before VAR overturned a penalty decision for a Dumfries handball. 

Empoli went ahead when Radu inadvertently turned into his own net after Patrick Cutrone nodded against the woodwork, though Ranocchia equalised with an audacious volley past Furlan.

Sanchez saw a tap-in ruled out for offside at the end of normal time, but Sensi blasted the winner into the top-left corner from the edge of the area in extra time.