The tournament has been moved from Colombia and Argentina to Brazil amid political unrest in the former nation and a spike in COVID-19 cases and deaths in the latter.
Brazil has also suffered horribly during the pandemic, although calls to postpone the tournament have been resisted despite some players from the host nation voicing their opposition.
Now Venezuela's attempts to snap a run of eight winless Copa America encounters with the Selecao – which has won six in that streak – look set to be compromised after news that 12 of its travelling party have tested positive for COVID-19.
"The health department was notified by CONMEBOL that 12 members of the Venezuelan national team’s delegation, including players and coaching staff, tested positive for COVID-19," a secretary of state for Brasilia statement read, with the match set to take place at Estadio Nacional in the Brazilian capital.
"They are all asymptomatic, isolated in single rooms and are being monitored."
The lack of any public statement on the matter from either CONMEBOL or the Venezuelan Football Federation (FVF), means it is unclear how many of the 12 are players.
The Athletic reported at least five players, including captain Tomas Rincon had tested positive, with local reports in Venezuela suggesting a flight for 14 replacement players had been chartered.
Teams named provisional squads of up to 60 for the tournament to mitigate against the potential effects of COVID-19 outbreaks.