Mauricio Pochettino's team has now lost its past three matches across all competitions after disappointing defeats to Panama and Mexico in the Nations League.

USMNT returns to action on Thursday (AEST) when it faces Switzerland in another friendly, before taking on Trinidad and Tobago in its first game of the Gold Cup.

Ahead of kick-off, Pochettino was forced to make several changes to his starting line-up, with many of his first-team regulars, including Christian Pulisic, absent.

Indeed, USMNT named eight Major League Soccer players in a starting XI for a match against UEFA opposition outside the December and January camps for the first time since May 2003.

That initially mattered little as the hosts went ahead with just 59 seconds on the clock through Jack McGlynn, who curled a stunning effort into the bottom-left corner.

Turkiye should have levelled in the 18th minute when Kenan Yildiz's cutback found Arda Guler, but the Real Madrid man could only fire over from inside the penalty area.

Guler, however, drew his side level in quite bizarre fashion soon after, with Johnny Cardoso's attempted clearance cannoning off the attacker and squirming past Matt Freese.

Turkiye went ahead three minutes later when Oguz Aydin's cross was blocked into the path of Kerem Akturkoglu, who fired a right-footed strike home. 

United States improved after the break and had two glorious chances to level, with Max Arfsten heading narrowly wide from Luca de la Torre's inviting cross.

Malik Tillman then saw his effort gathered by Berke Ozer after good work from substitute Tyler Adams, with USA growing in confidence as it searched for an equaliser.

Turkiye almost hit Pochettino's side with a sucker punch nine minutes from time after Tillman cheaply lost possession, but Baris Alper Yilmaz could only fire wide at the end of a fast break.