Mikel Merino broke Dutch hearts in the third minute of added time, to maintain an unbeaten run that now stretches to 22 competitive games.

The two powerhouses of world football meet again in Valencia on Sunday, with the winner of the tie to face France or Croatia in the semi-final.

"I feel like if we play like this, we have a very good chance of going through," Netherlands winger Jeremie Frimpong said.

"Today we brought a lot of energy, we had a lot of chances. You saw a good team today, so it's going to be fun to play -- and to watch for you guys," he added.

The omens were good for the hosts, who had never lost to Spain on home soil, and could count on raucous support from a sold-out De Kuip stadium in Rotterdam.

But Spain also had good memories of the stadium, the scene of their 2023 Nations League triumph, where they beat Croatia 5-4 on penalties.

The visitors struck first, benefitting from some defensive fraility and deft footwork from star winger Nico Williams.

Barcelona's 17-year-old prodigy Lamine Yamal dispossessed Jorrel Hato on the right side, finding club-mate Pedri who slotted into Williams in the box.

Williams effortlessly turned Lutsharel Geertruida and slid his shot past Bart Verbruggen in the Dutch goal to silence the orange hordes.

The hosts rallied strongly and got their reward on 27 minutes, the ball breaking for Liverpool's Cody Gakpo who beat Unai Simon at his near post.

The equaliser galvanised the Dutch, who enjoyed possession and pressure, knocking the ball around with confidence and creating several chances.

The best of these fell to Memphis Depay, recalled after a spell in the wilderness and he found himself unmarked in the Spanish box but struck his shot straight at Simon.

An acrobatic strike from AC Milan midfielder Tijjani Reijnders grazed the Spain bar and it was the Dutch who went into half-time in the ascendancy after a free-flowing first period.

Red card decisive 

The Oranje took the lead less than a minute into the second half, Jeremie Frimpong breaking swiftly down the right and squaring accurately to Reijnders, who swept his shot into the left corner.

Gakpo came close to stretching the lead even further in the 59th minute but Simon got down to his stinging shot along the ground.

Spain manager Luis De la Fuente made three substitutions in a bid to exert some pressure on the Dutch, but Verbruggen was untroubled until the 70th minute when he had to react smartly to a ball deflected off his own defender.

La Roja pushed for the equaliser with some intricate passing around the penalty box but lacked real penetration.

As pressure built, players on both sides became increasingly scratchy, culminating in a red card for Hato, who lunged at Robin Le Normand, catching his ankle.

That sparked a nervous last few minutes for the Dutch and the pressure eventually told.

Williams again harassed the Dutch defence, cutting inside from the left and releasing a shot that Verbruggen could only parry into the path of Merino for a tap-in.