A heavyweight showdown between the Western Conference leaders and the third-placed Lakers was effectively settled in the first half, as Los Angeles rattled in 15 three-pointers -- a franchise record -- to open up a 78-56 lead at the end of the second quarter.

The Lakers never looked like surrendering that hefty double-digit cushion as they closed out a comfortable win to silence the Oklahoma City home crowd.

The win saw the Lakers edge closer to securing one of the four remaining automatic playoff spots in the West after already-qualified Oklahoma City and Houston.

The Lakers poured in 22 three-pointers across the game, with Doncic responsible for five of them. Austin Reaves had four three-pointers in his 20 point haul, while LeBron James added 19 points.

Shai Gilgeous-Alexander led the Oklahoma City scoring with 26 points on an off-night for the Thunder, who shot just 43 percent from the field while making only 12-of-37 three-pointers.

James meanwhile said the Lakers had been determined not to let up after making a fast start against the Western Conference leaders.

"Between them and Cleveland, they're the best teams in the NBA," James said. "They're the number one team in the West so you can't let up no matter what the score is -- they're always going to make a push. That's why they are where they are at this part of the season.

- 'Good win for us' -

"So it's a really good win for us and we can build off it... we're just trying to build our habits right now, going into the final stretch of the year."

Reaves meanwhile believes the result augured well for the final week of the regular season, which reaches its conclusion on April 13.

Six teams are battling for four playoff spots in the West, from the third-placed Lakers (48-30) down to the eighth-placed Memphis Grizzlies (46-32).

"It's huge," Reaves said. "The way the standings are, you can go from third to eighth in the snap of a finger. So for us to come in and play such a good team the way we did tonight is big. Hopefully we can build on that momentum."

In San Francisco, meanwhile, the Golden State Warriors' five-game winning streak came to a halt with a 106-96 loss to the second-placed Houston Rockets.

Elsewhere on Sunday, the Cleveland Cavaliers missed the chance to lock up the No.1 seeding in the Eastern Conference after suffering a 120-113 home defeat to the Sacramento Kings.

The Kings, 10th in the West and battling to force their way into the play-in tournament, grabbed a precious victory courtesy of a 37-point performance from Zach LaVine, with DeMar DeRozan adding 28 points and Domantas Sabonis 27.

Cleveland, who lead the Eastern Conference by 4.5 games from Boston with a 62-16 record, had an injury scare in the third quarter when Donovan Mitchell hobbled off for treatment with what looked like an ankle problem.

Mitchell later returned to the game but was unable to stop the Cavs slipping to defeat.

Sacramento's victory meanwhile meant the Portland Trail Blazers and San Antonio Spurs were both eliminated from playoff contention in the West.

The Boston Celtics meanwhile kept their slim hopes of grabbing No.1 seed from Cleveland with a 124-90 rout of the Washington Wizards.