Fleetwood Town pulled off a giant-killing for the ages as it beat Premier League champion Arsenal 5-3 on penalties in the Carabao Cup.
Lazio moved back to the top of Serie A after thrashing 10-man Sassuolo 6-2 at MAPEI Stadium.
Harry Kane completed his long quest for football's highest individual honour, with the Bayern Munich and England striker winning the Ballon d'Or after a record-breaking season that cemented his status as one of the game's greatest goal-scorers.
Hansi Flick felt a lack of physical freshness cost Barcelona in a game he thought his team controlled, after it slumped to a 2-1 defeat against rival Real Madrid.
Kylian Mbappe scored twice, grabbing an 87th-minute winner, as Real Madrid claimed a 2-1 away victory over Barcelona in El Clasico.