WATCH the Madrid Open LIVE in Australia on beIN SPORTS | Sign Up to beIN to take advantage of our 7-day FREE TRIAL

The Spaniard battled to a 7-6 (8-6) 6-3 victory to earn his first win over a player ranked inside the top 20 since the ATP Finals back in 2022.

De Minaur beat Nadal last week in Barcelona, but the five-time Madrid champion was not to be denied this time in front of a crowd which included King Felipe VI along with football stars Zinedine Zidane and Vinicius Jr.

Emerging triumphant from an epic 77-minute opening set proved decisive, with Nadal more comfortable in the second as De Minaur missed an opportunity to become the first player to beat him in consecutive weeks since Novak Djokovic achieved the feat way back in 2011.

Nadal will take on Pedro Cachin in the third round after the Argentine dumped out Fances Tiafoe in three sets.

"I'm super happy to be able to be competitive against a great player like Alex and play over two hours," Nadal said.

"It means a lot to me and the atmosphere here is just a joke, so I can't thank enough everybody here.

"It still needs time [until I am back to my best]. I think for moments it has been a good level of tennis. I was able to do positive things, but still on and off.

"But I really believe that tennis hasn't been an issue for the last two years. More the physical issues. 

"If I am able to play weeks in a row and if I am able to play tennis, then I'm going to see how far I can go and how competitive I could be. But that's not the case yet, just step by step and let's see how I recover."

Elsewhere at the tournament, Australian Open champion Jannik Sinner, playing as the No.1 seed at a Masters 1000 event for the first time, cruised to victory over fellow Italian Lorenzo Sonego to start his campaign in style.

It took Sinner just 69 minutes to win 6-0 6-3 and improve to 26-2 in a remarkable 2024 season so far.

“I know Lorenzo quite well and we have a good friendship off the court, we play Davis Cup together, we practise a lot together,” Sinner said.

“The mental side was a little bit different than it used to be, so I'm just happy how I handled the situation. He didn't play at his best. I think we saw this. I wish him all the best for the rest of the season.”

Progress was harder to come by for Daniil Medvedev as he lost the opening set to Matteo Arnaldi, though the No.3 seed eventually battled through 2-6 6-4 6-4 to book a third-round clash with American Sebastian Korda.

There was a surprise result, though, with Brazilian qualifier Thiago Monteiro ending the fine recent form of Stefanos Tsitsipas with a 6-4 6-4 victory.

Tsitsipas was 10-1 on clay this year going into the match, but the No.6 seed crashed to a shock defeat just a week after Monteiro had lost in the first round of a Challenger Tour event in Portugal, marking a rapid reversal of his fortunes.

“Every week you have a new opportunity," Monteiro said. “These past few weeks I wasn’t feeling really good on the court. I was trying to do well at Challengers but it didn’t work.

“I just kept up the hard work, day by day. Even when I was not feeling good and not winning matches, I kept believing in myself, and this week it has paid off.

"For sure one of the biggest wins of my career. I knew it was a really tough match and I tried to just believe in myself all the time."